Aluminum

What is an adjuvant?

From the CDC: “An adjuvant is an ingredient of a vaccine that helps create a stronger immune response in the patient’s body.  In other words, adjuvants help vaccines work better. Some vaccines made from weakened or dead germs contain naturally occurring adjuvants and help the body produce a strong protective immune response. However, most vaccines developed today include just small components of germs, such as their proteins, rather than the entire virus or bacteria. These vaccines often must be made with adjuvants to ensure the body produces an immune response strong enough to protect the patient from the germ he or she is being vaccinated against.”

Professor Exley, "Cargo of Aluminum"

The most important video I have ever shared! Period.Hear Professor Exley, this week, in his own words, discussing the new study "Aluminium in brain tissue in autism." Pay attention to the DETAILS: It's not just the AMOUNT of the Aluminum that matters here (although its exceptionally high), it's the LOCATION of the Aluminum within the brain. Here's how he explains it:“Now, because I have seen the same cells that we will see at an injection site carrying a cargo of aluminum into the brain tissue of individuals who died with autism I would now say that we have to think very carefully about who receives a vaccine that includes an aluminum adjuvant. We need to think carefully, is this vaccine a life-saving vaccine or not? If it isn’t, don’t have it with an aluminum adjuvant.”Do you understand what he just said? He just said the aluminum from the injection site is carried, like "cargo," into the brain!! It changed his own mind about the role of aluminum in autism! He says:“I did not see a role for aluminum in autism. And I didn’t see a role for aluminum in vaccines in autism. I have to change my mind now on both of these. I have to change my mind that aluminum has a role in autism, I believe it now does.”Here's more detail:“Perhaps equally important if not more important were the microscopy studies. The microscopy studies enable us to identify where the aluminum was in the brain tissue. When we looked at our brains of people with a diagnosis of autism, we found something completely different and something we’ve never seen before as yet in any other set of human brains. We found that the majority of aluminum was actually inside cells, intracellular. Some of it was inside neurons, but actually the majority of it was inside non-neuronal cell populations. So we found that these cells were heavily loaded with aluminum. We also saw evidence that cells in the lymph and in the blood were passing into the brain, so they were carrying with them a cargo of aluminum from the body into the brain. This is the first time in any human brain tissue we have seen this so this is a standout and as yet unique observation in autism. For myself, it very much implicates aluminum in the etiology of autism. That doesn’t mean aluminum causes it, but it’s almost certainly playing a role in the disease.”Are the deniers in your life still trying to minimize the importance of this study? If they don't understand how important the LOCATION (which cells it's in, where it is) of the aluminum in the brain is to the findings, they don't understand the issue. By the way, this is EXACTLY what Vaccine Papers has been saying! Here's a simple brochure that explains this transport mechanism in a very clear way:http://vaccinepapers.org/wp-content/uploads/Autism-brochure-Color-8.5×11.pdfHere's Professor Exley's study:http://www.sciencedirect.com/science/article/pii/S0946672X17308763Here's an article I wrote about the study:https://medium.com/@jbhandley/new-study-massive-aluminum-levels-in-autism-brains-is-this-the-smoking-gun-for-vaccines-54ae85ec2a9cThis is–without peer–the most important science done to date that ties so much other science together. Read my article from back in February, watch this video, and your mind will be blown. Truth is staring us all in the face!! The leading expert in the world on the neurotoxicology of aluminum just said we need to rethink using it in vaccines!! Are you awake??? Here's my article from back in February:https://healthcareinamerica.us/did-chinese-scientists-find-autisms-missing-puzzle-piece-2d50be5b9122SHARE THIS WITH EVERYONE. Please!

Posted by J.B. Handley on Wednesday, December 6, 2017

 

From VaccinePapers.org:

“The Dwoskins had attended the Institute of Medicine (IOM) and FDA meetings on vaccines, where aluminum was briefly discussed. Both the IOM and FDA acknowledged that aluminum adjuvant toxicity had not been studied. Inferences had been made, based on single-vaccine studies, but experiments to measure the toxicity of aluminum adjuvant had never been done (except by Shaw). In particular, nobody had ever tested the effect of the total amount of aluminum adjuvant received from the vaccine schedule recommended by the CDC.”

For the results of aluminum-adjuvant injection experiments that replicated the CDC pediatric schedule, visit VaccinePapers.org. Key findings: Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes.

Dr. Humphries in Tampere, Finland, November 2015.

Dr. Suzanne Humphries breaks down the issue of aluminum into fine detail to help you better understand its use and effects.

Here she explains the different forms of aluminum adjuvants and how mislabeling has played a role in obfuscating the common ingredient of several vaccines that continues to cause injuries.

Aluminum Adjuvants

Abstract: Aluminum vaccine adjuvants: are they safe? Curr Med Chem. 2011;18(17):2630-7.

“Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science’s understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community.”

Aluminum exposure during pregnancy

Pregnant women are being told that they are being given vaccines to protect the baby in language that implies, if not outright states, that appropriate safety studies have been done. They have not. Pregnant women in the general population are in essence being used in ongoing clinical trials without their fully informed consent.

Over the years, data has been gathered in a haphazard fashion using voluntary registries set up by pharmaceutical companies and in adverse event reports to VAERS, both of which suffer from extreme under-reporting. VSD (Vaccine Safety Datalink) studies on the safety of vaccination during pregnancy mostly include only pregnancies with live-birth outcomes, and very few studies look at the long-term health effects on children. One such rare study on vaccination with the influenza vaccine during pregnancy (Zerbo et al) found a significant association with autism. Even the most elaborate and inappropriate application of adjustments and corrections could not make the association go away in the first trimester, so the authors simply dismissed the result as due to chance. This is not science. http://jamanetwork.com/journals/jamapediatrics/article-abstract/2617988

The impact of maternal immune activation during pregnancy, and the impact of exposure to various vaccine components, such as the placenta-crossing 250 mcg of aluminum in the Tdap, on long-term neurological development are not known, but there’s enough science indicating that extreme caution is warranted. The current push to vaccinate during every single pregnancy, as well as during every outbreak, comes without any understanding of the health effect of such frequent administration of three disease antigens (tetanus, diphtheria, pertussis) and other vaccine components. This is a small sampling of studies on one component, aluminum:

Aluminum Toxicity Studies

2002 “Neurological adverse events associated with vaccination.

2002 “The potential role of aluminium in Alzheimer’s disease.”

2004 “Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain.

2004 “Neurotoxic effects of aluminium among foundry workers and Alzheimer’s disease.)

2007 “Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice.

2007 “Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.

2007 “Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer’s disease.

2007 “Inflammation, neurodegenerative diseases, and environmental exposures.

2008 “Role of metal ions in the abeta oligomerization in Alzheimer’s disease and in other neurological disorders.

2009 “Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction.

2009 “Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.”

2009 “Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells.

2011 “Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.”

2011 “Aluminum vaccine adjuvants: are they safe?

2011 “Metal ions affecting the neurological system.

2013 “Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep.

2013 “How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale.

2014 “Aluminum-induced entropy in biological systems: implications for neurological disease.”

2014 “Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy?

2014 “A sudden onset of a pseudo-neurological syndrome after HPV-16/18 AS04-adjuvated vaccine: might it be an autoimmune/inflammatory syndrome induced by adjuvants (ASIA) presenting as a somatoform disorder?

2014 “Elevated brain aluminium and early onset Alzheimer’s disease in an individual occupationally exposed to aluminium: a case report.

2014 “Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration.

2014 “Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes.

2014 “Oxidative stress and mitochondrial dysfunction in aluminium neurotoxicity and its amelioration: a review

“Being involved in the production of reactive oxygen species, aluminium may impair mitochondrial bioenergetics and may lead to the generation of oxidative stress. In this review, we have discussed the oxidative stress and mitochondrial dysfunctions occurring in Al neurotoxicity. In addition, the ameliorative measures undertaken in aluminium induced oxidative stress and mitochondrial dysfunctions have also been highlighted. “

2014 “Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.

2014 “Aluminium Induced Endoplasmic Reticulum Stress Mediated Cell Death in SH-SY5Y Neuroblastoma Cell Line Is Independent of p53”

2015 “Trace elements in scalp hair samples from patients with relapsing-remitting multiple sclerosis.

2015 “Correlation of aluminum and manganese concentration in scalp hair samples of patients having neurological disorders.

2015: “Biopersistence and brain translocation of aluminum adjuvants of vaccines

“We previously showed that poorly biodegradable aluminum-coated particles injected into muscle are promptly phagocytosed in muscle and the draining lymph nodes, and can disseminate within phagocytic cells throughout the body and slowly accumulate in brain. This strongly suggests that long-term adjuvant biopersistence within phagocytic cells is a prerequisite for slow brain translocation and delayed neurotoxicity.”

2016: “Insight into the cellular fate and toxicity of aluminum adjuvants used in clinically approved human vaccinations

“We demonstrate that not all aluminium adjuvants are equal neither in terms of their physical properties nor their biological reactivity and potential toxicities both at the injection site and beyond. High loading of aluminium oxyhydroxide in the cytoplasm of THP-1 cells without immediate cytotoxicity might predispose this form of aluminium adjuvant to its subsequent transport throughout the body including access to the brain.”

2016 “Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil.”

“Vaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals. We sought to evaluate the effects of Al adjuvant and the HPV vaccine Gardasil versus the true placebo on behavioral and inflammatory parameters in female mice.”

2016 “Aluminum adjuvants of vaccines injected into the muscle: Normal fate, pathology and associated disease.”

“Although generally well tolerated on the short term, it has been suspected to occasionally cause delayed neurologic problems in susceptible individuals. In particular, the long-term persistence of aluminic granuloma also termed macrophagic myofasciitis is associated with chronic arthromyalgias and fatigue and cognitive dysfunction. Safety concerns largely depend on the long biopersistence time inherent to this adjuvant, which may be related to its quick withdrawal from the interstitial fluid by avid cellular uptake; and the capacity of adjuvant particles to migrate and slowly accumulate in lymphoid organs and the brain, a phenomenon documented in animal models and resulting from MCP1/CCL2-dependant translocation of adjuvant-loaded monocyte-lineage cells (Trojan horse phenomenon). These novel insights strongly suggest that serious re-evaluation of long-term aluminum adjuvant phamacokinetics and safety should be carried out.”

2017 Effects of Aluminium on Rat Brain Mitochondria Bioenergetics: an In vitro and In vivo Study

“The observed effects also included both an alteration in mitochondrial transmembrane potential and a decrease in oxidative phosphorylation capacity when relatively high concentrations of aluminium were added to the isolated mitochondria. These findings contribute to explain both the ability of aluminium to generate oxidative stress and its suggested potential to act as an etiological factor by promoting the progression of neurodegenerative disorders such as Parkinson’s disease.”

2017 The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?

“Evidence of the neurotoxicity of aluminium cations (Al3+) includes: an association between chronic aluminium exposure and the development of AD; the involvement of aluminium adjuvants in the development of ASIA; and epidemiological evidence pointing to an association between the use of aluminium adjuvants and ASD.”

“Aluminium has no known beneficial physiological action in the human body and some genetic polymorphisms predispose to a greater susceptibility to its adverse effects. Therefore, a strong case can be made for avoiding unnecessary exposure to environmental sources of aluminium salts, especially on the part of children, pregnant mothers and women of child-bearing age who may become pregnant. Such avoidance need not lead to hardship or inconvenience; aluminium cookware may be replaced by safer alternatives, while aluminium-containing antiperspirants, potentially implicated in the rise of cases of breast cancer particularly affecting the upper outer quadrant of the mammary gland, may be replaced by non-aluminium versions. The use of aluminium salts in medical products is a more contentious issue. While antacids are available which do not contain aluminium salts, the avoidance of immunisations which do not contain aluminium salts as adjuvants has wider political and financial implications. It would seem prudent to try to find an alternative to aluminium adjuvants as soon as possible and phase out their use.”

“Moreover, aluminium exposure is associated with the production of pro-inflammatory cytokines and chemokines and with the development of chronic oxidative stress, mitochondrial dysfunction and glial activation or dysfunction; these changes in turn are associated with ASD.”

2017 Aluminium in brain tissue in autism.

“The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissue and may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder.”

 

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