“Both epidemiologic and mechanistic research suggest that most individuals who experience an adverse reaction to vaccines have a preexisting susceptibility. These predispositions can exist for a number of reasons—genetic variants (in human or microbiome DNA), environmental exposures, behaviors, intervening illness, or developmental stage, to name just a few—all of which can interact as suggested graphically in Figure 3-1 [left]. Some of these adverse reactions are specific to the particular vaccine, while others may not be. Some of these predispositions may be detectable prior to the administration of vaccine; others, at least with current technology and practice, are not. Moreover, the occurrence of the adverse event is often the first sign of the underlying condition that confers susceptibility.” Adverse Effects of Vaccines: Evidence and Causality (2012) Institute of Medicine
In the past decade, the amount of new science has been staggering. Of most importance to the topic of vaccination, and vaccine injury–especially slowly-evolving chronic health issues–is the science on the gut-brain connection. It now known that 70% of the immune system is in the gut; and it is known that many neurological and developmental disorders have origins in gastrointestinal disorders. The science on the safety and impact of vaccines cannot be declared “settled” in the face of so many scientific discoveries that have not yet been fully explored. Chief among those discoveries is this:
“They’ll Have to Rewrite the Textbooks”
The University of Virginia announced in the March 21, 2016 issue of UVAToday the discovery that the lymphatic system is directly connected to the brain.
“It’s a stunning discovery that overturns decades of textbook teaching: researchers at the School of Medicine have determined that the brain is directly connected to the immune system by vessels previously thought not to exist.”
“The brain and the adaptive immune system were thought to be isolated from each other, and any immune activity in the brain was perceived as sign of a pathology. And now, not only are we showing that they are closely interacting, but some of our behavior traits might have evolved because of our immune response to pathogens,” explained Jonathan Kipnis, chair of UVA’s Department of Neuroscience.”
“But the true significance of the discovery lies in its ramifications for the study and treatment of neurological diseases ranging from autism to Alzheimer’s disease to multiple sclerosis.”
Everything about vaccines and vaccine administration should be reevaluated based on this and other recent scientific discoveries. The true scope and magnitude of adverse events are not known. The science is not settled.
What is Personalized Medicine?
Personalized medicine is a medical approach in which decisions and product administration are tailored to an individual’s genetics, health, environment, and lifestyle, to maximize benefits and minimize risk.
Because no medicine is one-size-fits-all, PERSONALIZED MEDICINE and PERSONALIZED VACCINE SCHEDULES are the only ethical approach if vaccination is chosen. School requirements and policies that do not allow for individualized medicine put children at risk of injury.
Personalized medicine also respects individual choice. InformedChoiceWA recognizes that diet, lifestyle, and behavior choices play important roles in protecting personal and community health, as do access to clean water, proper sanitation, adequate housing, and access to medical care.
Personalized Medicine and the Future of Immunity
All fields of medicine are moving toward personalization, from cancer treatment to cardiovascular disease, incorporating the latest science into products, treatments, and administration to avoid unnecessary risk.
“ . . .the idea not so much that we would make a vaccine for an individual person, but that we would begin to use age, disease state, medical condition, genomic information, and systems biology or ‘vaccinomics’ information began to do several things: Predict who should get a vaccine, what dose they should get in how many doses, predict whether they’re going to have a response to that vaccine, predict whether they’re at risk for the disease that we’re immunizing them for, and predict whether they’re going to have a side effect for that vaccine.” Dr. Gregory Poland, Mayo Clinic
“. . .the fact that vaccines are delivered to billions of people without preliminary screening for underlying susceptibilities is thus of concern. Indeed, it is naïve to believe that all humans are alike.” Vaccines and Autoimmunity by Shoenfeld et al, 2015
“CBER’s Office of Vaccines Research and Review together with the Genomics Evaluations Team for Safety (GETS) are involved in several research collaborations that focus on identification of genetic risk factors associated with adverse reactions to vaccines.” PAVING THE WAY FOR INDIVIDUALIZED MEDICINE, October 2013, FDA
“Many factors may influence the immune response to vaccination. These include the presence of maternal antibody, nature and dose of antigen, route of administration, and the presence of an adjuvant (e.g., aluminum-containing material added to improve the immunogenicity of the vaccine). Host factors such as age, nutritional factors, genetics, and coexisting disease, may also affect the response.” CDC Pink Book
“. . . the vaccine research team at Mayo Clinic — one of the world’s largest, most respected and most prolific — promotes the growing discipline of “adversomics,” which aims to understand the adverse effects that can come of vaccines. The science here is daunting, since the variables that could cause a vaccine to do harm involve “a complex interaction of past exposures and infections, current physical and emotional health, and the individual’s genome and microbiome . . . Today’s vaccines are failing. Personalized vaccines that reflect an individual’s genetic profile are coming. Traditional vaccines work on a century-old model of “Isolate, Inactivate, Inject” — the tried-but-not-always-true method of making a vaccine by isolating a pathogen, stripping it of its potency and then injecting it into us. This crude approach to developing a vaccine, reliant on observation rather than theory, becomes all the cruder by delivering it in one-size-suits-all fashion.” Lawrence Solomon
Read the IOM Report:
The Vaccine Friendly Plan by Dr. Paul Thomas:
The Ask Dr. Sears website: